Plasma levels of orexin-A and BMI in the present study

Tuesday, December 2nd, 2014 No Commented
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It has yet to be determined whether plasma and CSF levels of orexin-A correlate with each other, and whether plasma orexin-A levels are regulated by a negative feedback system of the arousal response. Reduced levels of orexin-A in the CSF and a substantial reduction in the number of orexin neurons, specifically in the hypothalamus, have been reported in narcoleptic patients. Combined with the lower levels of plasma orexin-A observed in narcoleptic patients, plasma levels of orexin-A may represent changes in the number or activity of orexin neurons in the CNS. It is possible that the regulation of plasma orexin-A levels differs between narcoleptic patients and patients with OSAHS. In the present study, we acknowledge one important limitation, namely, we did not obtain CSF samples from our patients to measure the levels of orexin-A. However, the correlation of plasma orexin-A levels and the severity of OSAHS, and the simplicity of specimen collection may support the usefulness of plasma orexin-A as a biological marker of OSAHS health care store.

No significant correlation was observed between plasma levels of orexin-A and BMI in the present study. However, Adam et al reported that plasma orexin-A levels correlated negatively with BMI and that lower levels of plasma orexin-A are present in obese individuals, suggesting that orexin is involved in the regulation of human energy metabolism. In addition to their potent effects on appetite, orexins may interact with the CNS system, controlling sympathetic outflow and cardiovascular function. Orexin-A, when injected into the lateral cerebroven-tricle, induced an increase of mean arterial pressure and heart rate in conscious rats. The effects of orexin peptides have been uniformly reported as excitatory, and orexin neurons project to monoamin-ergic cell groups. These findings may explain the relation between underlying narcolepsy symptomatology and orexin deficiency canadian healthcare. The posterior hypothalamus containing orexin neurons has been implicated in arousal state control. The projection from orexin neurons to monoaminergic cell groups, which include histaminergic, serotonergic, and noradrenergic cells, could be related to arousal-state regulation, while monoaminergic neurons inhibit the REM-activated neurons in the cholinergic nucleus. Therefore, it is probable that the orexin system may have a neuromodulatory effect on arousal states. Given the putative role of orexin in sleep-wakefulness function, increased orexin transmission, reflected as increased plasma orexin-A levels, may affect the arousal response in patients with OSAHS.

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